Ronald W. Davis
Stanford University
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Primary Section: 26, Genetics Secondary Section: 21, Biochemistry Membership Type:
Member
(elected 1983)
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Research Interests
As a geneticist, I focus on developing new techniques and instruments. Using the Saccharomyces cerevisiae sequence, new technology is being developed to conduct whole genome analysis, including the functions of the open reading frames by deletion analysis, gene expression level, gene fusion, and protein product and drug discovery. New technologies, instruments, and software are being developed to automate many of the procedures. Automated instruments for plaque/colony picking, DNA preparation, PCR, and a 96-well oligonucleotide synthesizer have been constructed. Oligonucleotides and genes for whole genomes are synthesized or arrayed on glass microarrays for functional and expression analysis. Many of these analyses are being applied to the newly identified pathogenic Saccharomyces cerevisiae strain. Similar developments are being applied to the higher plant Arabidopsis. Specifically, gene regulation is being investigated by hormone and stress response. Whole genome sequencing is being conducted or initiated for Candida albicans, Arabidopsis thaliana, Chlamydia, Rhizobium, Plasmodium (malaria), and human.
